A Clinical Study of Micronized Acellular Dermal Matrix Collagen Paste Application with Negative Pressure Wound Therapy

Abstract

Introduction Micronized cadaveric acellular dermal matrix (mADM) paste, which functions by filling vertical wound planes with acellular dermal matrix particles and gelatin suspension, is a novel option for the treatment of hard-to-heal wounds. We aimed to evaluate the clinical outcome of mADM paste used in conjunction with negative pressure wound therapy (NPWT) in the treatment of hard-to-heal wounds. Methods This prospective clinical trial enrolled 20 patients with hard-to-heal wounds from January 2016 to January 2017. Wound healing was assessed at 1, 2, 3, and 4 weeks after treatment. Wound size and depth and patient satisfaction were recorded at each follow-up. Results The area of the wound was measured in all study participants, which decreased from an average of 15.48±22.38 cm2 at the start of the study to 8.97±17.73 cm2 after 4 weeks, with a reduction rate of 59.10%±31.76% (P<0.0001). Two weeks into the study, there was a significant decline in the wound depth compared with the previous week. Conclusion mADM with NPWT provides effective wound healing. It is more comfortable for the patients and less time-consuming for the nursing staff; thus, this treatment deserves a prominent place in the care of patients with hard-toheal wounds.